A double-blind clinical trial from Mashhad University of Medical Sciences, published in the journal Scientific Reports 2025, reveals that taking crocin (the main carotenoid in saffron) for eight weeks can reduce certain inflammatory markers in adults with metabolic syndrome. The study, conducted in just 28 people, shows that crocin helped reduce blood levels of IL-2, IL-10, VEGF and interferon gamma, immune system signals associated with chronic inflammation, without significant changes in cholesterol or glucose. Although the sample size is small and the result should be interpreted with caution, these findings open a window on how small physiological adjustments can influence our internal balance.
Bodies that rest when inflammation decreases
Small daily gestures to promote balance and rest
The role of physiological rhythms: melatonin, serotonin and calming plants.
Melatonin 1 mg and 5-HTP with relaxing plants to facilitate the onset of rest, as a complement to specific nocturnal habits.
Frequently asked questions about sleep, inflammation and natural support.
Can regulating inflammation help improve my sleep?
Yes, when pro-inflammatory activity in the body decreases, as indicated by the decrease in certain markers after taking crocin, it promotes an internal environment that allows for a more stable and deeper sleep.
How does 4Sleep support my natural cycles if I have stress or changes in routine?
4Sleep supports your physiology with melatonin (1 mg), helping to signal the body when to begin resting. Its plant extracts help relax the mind and body without aggressive sedative effects or addiction.
Should I combine the antioxidants in my diet with supplements to rest better?
It is not mandatory, but complementary. A diet rich in colorful fruits or spices provides natural antioxidants; supplements like 4Sleep reinforce specific sleep pathways when you need them in a timely manner.
Does the 4Sleep formula cause daytime sleepiness?
No. It does not cause hangover or residual sleepiness, as it contains doses adjusted according to European guidelines (melatonin 1 mg) together with calming plants such as valerian or chamomile.
Why choose formulas with standardized ingredients?
Standardized extracts always guarantee the same amounts of active ingredients (such as 5-HTP or apigenin), which allows you to rely on real efficacy batch after batch.
