A study in the Journal of microbiology and biotechnology 2025 tested a low-molecular-weight collagen peptide supplement for eight weeks in 70 healthy adults. People taking the collagen showed less wrinkles, better elasticity, more hydration and finer pores compared to placebo. The effects were maintained two weeks after stopping the product and no safety concerns were observed.
For the skincare professional, these results indicate that oral collagen can provide visible and measurable changes in skin texture, firmness and moisture. The impact appears to be particularly relevant from middle age onwards, when the loss of collagen and hyaluronic acid accelerates and the skin appears drier and less voluminous.
What this study on collagen and skin really did
The trial was randomised, double-blind and placebo-controlled, meaning neither participants nor researchers knew who was taking collagen or placebo. For eight weeks, 70 adults aged 20 to 59 years took 1650 mg of low-molecular-weight collagen peptides or an inactive tablet every day.
Wrinkles, elasticity, hydration, skin density, pore size and sebum production were measured with high-precision dermatological equipment. The changes were clear in practical terms, with shallower wrinkles, more elastic and better hydrated skin in the collagen group. In addition, the number and volume of pores decreased and sebum secretion was regulated.
The effects were maintained for two weeks after discontinuation of the supplement, suggesting an action that modifies the internal structure of the skin and not just a transient effect. There were no adverse events attributable to the product, supporting its use as a safe ingredient in healthy adults.
How collagen peptides act on skin structure
The skin is supported by an internal network called the extracellular matrix, consisting mainly of collagen and hyaluronic acid. With age and sun exposure, this network loses density and organisation, resulting in wrinkles, sagging and dryness.
Hydrolysed collagen is obtained by fragmenting collagen into small peptides that are easily absorbed by the intestine. These peptides, rich in amino acids such as glycine and proline, enter the bloodstream and reach the dermis, where they stimulate fibroblasts, the cells that make new collagen and hyaluronic acid.
The study observed improvements in elasticity, dermal density and deep hydration, which fit with this physiological pathway. By reinforcing the internal matrix, the skin gains consistency, retains water better and wrinkles become shallower. The reduction in pore size and excess sebum also reflects a more compact and balanced tissue.
Daily habits that support natural collagen synthesis
Collagen does not work alone. For the skin to maintain its structure, it needs sufficient protein, vitamin C, minerals and sensible sun exposure. A diet rich in fruits, vegetables, legumes, nuts and quality proteins provides the building blocks and co-factors needed to manufacture and protect your own collagen.
Limiting smoking and excess alcohol is key, as both accelerate collagen degradation and increase oxidative stress. Daily use of sunscreen, even on cloudy days, reduces UV damage to collagen fibres and hyaluronic acid in the dermis.
Regular movement also helps. Physical activity improves circulation and nutrient supply to the skin, which promotes repair processes. Getting enough sleep and managing stress contributes to a more stable hormonal environment, which supports the regeneration of connective tissues.
How Collagen Complex fits into this physiological pathway
Nutribiolite Collagen Complex follows the same logic as the clinical trial, working from within the skin matrix with hydrolysed collagen and nutrients involved in its synthesis and protection. Its central ingredient is low molecular weight Peptan Type 1 bovine hydrolysed collagen, which provides the amino acids that the body uses to rebuild collagen in skin and connective tissues.
The formula adds buffered vitamin C, which acts as an essential cofactor in the formation and stabilisation of collagen fibres. It also includes hyaluronic acid in the form of sodium hyaluronate, linked to water retention in the extracellular matrix, which supports skin hydration and volume.
Minerals such as magnesium, zinc and selenium, in bioavailable forms such as magnesium citrate, zinc bisglycinate and L selenomethionine, contribute to protein synthesis, protection against oxidative stress and the normal maintenance of skin, hair and nails. Preformed vitamin A and biotin complete the support for cell regeneration and skin surface care.
Bamboo extract provides natural silica, a structural cofactor involved in collagen formation and connective tissue stability. Together, Collagen Complex offers a holistic approach that supports the natural processes of skin, joints and nails, in line with evidence linking oral collagen to improvements in skin firmness and hydration.
Hydrolysed collagen supplement with hyaluronic acid, vitamins and minerals, designed for adults looking to care for skin and connective tissues from the inside out.
What you can take away from this study into your routine
In summary, the clinical trial supports that low molecular weight collagen peptides, taken orally, can measurably improve wrinkles, elasticity, hydration and pore appearance in healthy adults. These effects are in addition to lifestyle habits that protect one’s own collagen, such as a diet rich in antioxidants and good photoprotection.
For many people, combining a careful lifestyle with a well-formulated collagen supplement can be a consistent way to support the internal structure of the skin and other connective tissues. The key is consistency and understanding that it is about accompanying physiological processes, not seeking instant solutions.
This content is informative and is not a substitute for the advice of a healthcare professional.
Frequently asked questions
What is the difference between dietary collagen and an oral supplement?
Dietary collagen is digested into fragments of varying size. Hydrolysed collagen supplements, such as low molecular weight peptides, are designed to generate small peptides that are more easily absorbed by the gut and delivered to the skin and other connective tissues.
How long does it usually take to see changes in the skin with oral collagen?
The study analysed observed improvements within four to eight weeks. In practice, many people report gradual changes in hydration and elasticity within the first few months, provided they maintain consistent intake and healthy lifestyle habits.
Does Collagen Complex work only for skin or also for joints and nails?
The formula is designed to support collagen synthesis and the maintenance of connective tissues. Peptan Type 1 collagen, together with minerals such as zinc and selenium and vitamins such as biotin, contributes to the care of skin, hair, nails and the support of bones and joints within an overall wellness approach.
Can I take Collagen Complex all year round?
It can be used continuously in adults seeking sustained support for skin and connective tissues, always respecting the recommended dose of three capsules a day. If you are pregnant, breastfeeding, taking medication or have a medical condition, it is advisable to consult a healthcare professional before starting any supplementation.
Is taking collagen enough or do I need to take care of other skin conditions?
Oral collagen is a support, not a substitute for a foundation of healthy habits. To take care of your skin, it is advisable to combine a balanced diet, daily sun protection, avoid smoking and excess alcohol, and maintain good hydration. A supplement such as Collagen Complex can be integrated into this set of measures to strengthen the skin’s internal structure.
