Although this study focused on people with narcolepsy, those whose biological clock is particularly disturbed, their findings open a door to new ways of balancing internal rhythms without resorting exclusively to drugs. The research was funded by independent Chinese national agencies, reinforcing its scientific neutrality.
Mechanisms: when the brain listens to the body’s signals
The vagus nerve is one of the great messengers between our brain and internal organs. In this trial, stimulating it from the skin of the ear helped regulate key brain areas to keep us alert during the day and facilitate smooth transitions to rest at night. Increased activity was seen in brainstem regions related to sustained attention and positive changes in circuits linked to mood and perceived well-being.
The key is how these signals modulate chemical pathways: noradrenaline for wakefulness, serotonin to regulate emotions and melatonin as the final orchestra of the circadian cycle. Thus, small interventions can help restore that precise dance between light, mind and rest.
Habits that pave the way: synchronising with your natural rhythm
You don’t need advanced technology to start taking care of your internal cycles. Science confirms that regularity is the best ally: going to bed at the same time every night, having a light dinner, reducing intense lights before going to sleep or practising deep breathing are gestures that send clear messages to the brain: “it’s time to relax”.
Tryptophan-rich foods such as nuts or oatmeal, soothing bedtime routines and avoiding screens make it easier for your body to naturally manufacture serotonin and melatonin. These habits strengthen the same physiological pathways activated by modern clinical interventions.
When you are looking for extra support: 4Sleep accompanies your physiology.
There are times when the body needs a clearer signal to go into rest mode: prolonged stress, time changes or restless nights after an intense day. This is where 4Sleep, a food supplement formulated with melatonin (1 mg), standardised Griffonia extract (natural source of 5-HTP), valerian and chamomile, can support your night-time routine from the inside out.
Each capsule works according to the same principle observed in science: reinforcing the natural pathways that lead from an active state to deep rest without forcing or blocking biological processes. Melatonin helps mark the onset of rest; Griffonia provides 5-HTP to support internal serotonin production; valerian and chamomile gently relax without creating dependence or residual drowsiness.
Melatonin 1 mg and 5-HTP with relaxing plants to facilitate the onset of rest, as a complement to specific nocturnal habits.
Frequently asked questions about stable sleep and natural supplements
What is the recent evidence on sleep-wake balance based on?
The clinical trial cited above used atrial vagal stimulation to increase stability between active wakefulness and deep rest using mild electrical signals that modulated brain regions responsible for arousal. This advance adds to previous research on the benefits of regular routines and healthy habits.
Why is it important to reinforce physiological pathways before sleep?
Our nervous system responds to both external (dim light, silence) and internal (endogenous melatonin) cues. Creating a coherent environment makes it easier for these chemical pathways to work harmoniously, preparing the mind and body for better rest.
How does 4Sleep fit in with what neuroscience has learned?
4Sleep works according to the same physiological principles observed in recent studies – it supports natural serotonin production (with Griffonia) and incorporates safe exogenous melatonin along with proven calming extracts such as valerian or chamomile. All designed to accompany healthy routines without generating dependence.
Can a supplement replace basic habits such as eating a light dinner or having regular schedules?
No. A supplement such as 4Sleep is an occasional support when habits need reinforcement, but it never replaces the central importance of stable routines, nor can it compensate for disordered lifestyles or excessive use of screens before bedtime.
How long after starting a routine with natural support do I usually notice an effect?
Gradual improvements are usually noticeable after two to four weeks if consistency in relaxing night-time schedules is combined with responsible use of the supplement according to professional guidelines.
This content is for information only and is not a substitute for professional advice.
