A review published in the 2025 issue of *Frontiers in Aging* analysed 48 high-quality publications on natural strategies for modulating oestrogenic activity in postmenopausal women. Dietary phytoestrogens, at doses of 50–80 mg/day of isoflavones, reduced severe hot flushes by up to 92% in the most prominent trial. The review also identified black cohosh and red clover as botanicals with evidence of efficacy for vasomotor symptoms.
These findings are relevant to women in perimenopause and postmenopause. Some 40–50 per cent of Western women seek non-hormonal alternatives due to safety concerns associated with hormone replacement therapy. The evidence reviewed points to multi-pronged approaches combining phytoestrogens, micronutrients and standardised botanicals.
How isoflavones work during the menopause according to current evidence
Soya isoflavones, primarily genistein and daidzein, act as selective oestrogen receptor modulators, with a preferential affinity for the beta receptor. This tissue selectivity explains why the 2025 review in *Frontiers in Aging* confirmed their safety for reproductive tissues in postmenopausal women, according to the EFSA assessment cited in the paper.
Red clover provides a different profile of isoflavones: formononetin and biochanin A. A meta-analysis of eight trials included in the review showed that red clover isoflavones significantly reduced the daily number of hot flushes, with the greatest effects observed in postmenopausal women experiencing more than five episodes per day. Combining both sources provides a more comprehensive spectrum of isoflavone subtypes.
Why diet alone does not provide the doses studied in Western women
The range of isoflavones with a documented effect in the trials included in the review ranges from 50 to 80 mg/day. Achieving these figures through the typical Western diet alone would require levels of soya consumption that are uncommon in Spain and Latin America. The standardisation of plant extracts is precisely the method that allows consistent and verifiable amounts to be obtained with each dose.
Without standardised extracts, the concentration of isoflavones varies depending on the plant variety, processing and batch. The review notes that the lack of standardisation in botanical products remains one of the main obstacles to clinical reliability. Choosing a supplement containing extracts with a declared standardisation percentage directly addresses this limitation.
What role does vitamin E play in oestrogenic activity, according to the paper?
The review notes that vitamin E compounds have demonstrated oestrogenic activity, activating the ERα and ERβ receptors and stimulating oestrogen-dependent gene transcription. A meta-analysis of 10 studies involving 1,100 participants found that the combination of vitamin E and omega-3 reduced the severity of hot flushes, although vitamin E alone did not show a significant effect on this parameter in that specific analysis.
These findings were obtained from postmenopausal and perimenopausal women. The natural form of vitamin E, D-alpha-tocopherol, is the variant used in the reference trials and is associated with greater bioavailability compared with the synthetic forms, dl-alpha-tocopherol.
How Nutribiolite’s Menovon aligns with the physiological rationale of the study
The link between the paper and Menovon is direct: the same botanical ingredients highlighted in the review—red clover, soya and black cohosh—form part of its formula in standardised extracts. Each capsule provides 40 mg of total isoflavones, derived in equal parts from standardised red clover extract (8% isoflavones) and soya extract (40% isoflavones). This dual source provides a combined profile of genistein, daidzein, formononetin and biochanin A.
Black cohosh is present as a dry rhizome extract standardised to 2.5% triterpene glycosides. The paper includes a retrospective study of 174 symptomatic menopausal women in which Cimicifuga racemosa extract significantly improved scores on the menopause assessment scale. Menovon also contains chaste tree standardised to 0.5% vitexin, a botanical traditionally used to support the balance of the female cycle.
Vitamins complete the formula in bioactive forms. Vitamin E is present as natural D-alpha-tocopherol, the form used in the reference studies on oestrogenic activity cited in the paper. Vitamin B6 is included as pyridoxal-5-phosphate (P5P), the active coenzyme ready for use by the body without any prior conversion steps. Vitamin D3, in the form of cholecalciferol, helps maintain bones in a healthy condition, which is particularly important during the post-menopausal stage.
The formula contains no synthetic additives, magnesium stearate, silicon dioxide, colourings or preservatives. Gluten-free, lactose-free and GMO-free. 90 capsules for three months’ supplementation at a dose of 1 capsule per day.
Menovon combines red clover and soya isoflavones with black cohosh, chaste tree and vitamins D3, B6 (in the form of P5P) and natural vitamin E, in a standardised formula free from synthetic additives.
Five frequently asked questions about isoflavones during the menopause and Menovon
What is the difference between soya isoflavones and red clover isoflavones?
Soya mainly provides genistein and daidzein. Red clover mainly contains formononetin and biochanin A. Each subfamily interacts with oestrogen receptors with different affinities. Combining both sources provides a more varied profile of isoflavones in each dose.
How long is it recommended to continue taking the supplement to see results?
The trials included in the 2025 Frontiers in Aging review lasted between 6 and 12 weeks. Everyone responds differently. Consistent supplementation as part of a balanced lifestyle is recommended to get the most out of the supplement.
Does Menovon contain any synthetic additives?
No. Menovon contains no magnesium stearate, silicon dioxide, artificial colourings or preservatives. The formula is clean, gluten-free, lactose-free and GMO-free.
When and how should Menovon be taken?
It is recommended to take one capsule a day, preferably with a meal and plenty of liquid. Each bottle contains 90 capsules, equivalent to three months’ supply.
Can I take Menovon alongside other supplements or medicines?
Menovon can be incorporated into your daily routine alongside other supplements. Scientific reviews indicate that red clover may enhance the anticoagulant effect of warfarin. If you are taking any medicines or have any health conditions, consult a healthcare professional before combining it with other products.
This content is for information purposes only and is not a substitute for advice from a healthcare professional.
