100% natural food supplement, without synthetic additives, which combines Melatonin, and the extracts of Griffonia seed (source of 5-hydroxytryptophan or 5HTP), Valerian root and Chamomile flower.
4Sleep is an effective natural formula to favor the biological processes associated with relaxation, improving the quality of sleep and reducing the time needed to fall asleep.
🌙_Melatonin, the sleep hormone responsible for regulating the body’s biological clock (circadian or sleep-wake cycle) and energy metabolism. Melatonin helps decrease the time it takes to fall asleep1.
🌙_Griffonia extract, standardized to 20% in 5HTP, the precursor amino acid in the biosynthesis of serotonin, the “well-being hormone”, which in turn is converted to melatonin during sleep. Griffonia improves brain activity2.
🌙_Valerian root extract, standardized to 0.8% valerenic acid, which helps to fall asleep3, supports mental well-being in cases of tension and stress4.
🌙_Chamomile flower extract, standardized to 1.2% in apigenin, which contributes to maintaining a healthy sleep5.
Melatonin is a hormone produced mainly by the pineal gland (located in the back of the brain), derived from another hormone, serotonin. Melatonin is extremely important in regulating the body’s biological clock (circadian cycle or sleep-wake cycle) and energy metabolism. Each capsule of 4Sleep contains 1mg of melatonin.
Melatonin helps alleviate the subjective sensation of jet lag. The beneficial effect is obtained with a minimum intake of 0.5 mg, which should be taken shortly before bedtime on the first day of travel and a few days after arrival at the destination1.
Melatonin helps reduce the time needed to fall asleep. The beneficial effect is obtained with an intake of 1 mg of melatonin shortly before going to sleep1.
5-HTP, also known as oxitriptan, is the precursor amino acid in the biosynthesis of serotonin, a neurotransmitter that plays a key role in regulating almost all functions of the central nervous system, such as mood, anxiety, stress, appetite, cognition, and sexual behavior. Each capsule of 4Sleep contains 245mg of Griffonia seed extract standardized to 20% 5HTP, which is equivalent to 49mg of 5HTP per capsule (recommended daily allowance).
The 4Sleep Valerian root extract is standardized to 0.8% valerenic Acid. This substance has been shown to have the ability to modulate GABA-A receptors6, 7, producing a suppressive effect on neuronal activity. Valerian helps shorten the time it takes to fall asleep3.
Chamomile flower extract is well known for its relaxing properties, due to the presence of apigenin, a flavonoid polyphenol. According to several studies, apigenin can act as a second-order modulator of GABA-A receptors, that is, a modulator that enhances the effect of endogenous agents that modulate GABA-A receptors8. Chamomile helps maintain a healthy sleep5. 4Sleep’s chamomile extract is standardized to 1.2% apigenin.
Other ingredients: maize starch. Vegetable capsule (hydroxypropylmethylcellulose).
+ Instructions
Recommended daily dose: Take one capsule daily with sufficient liquid, 1 or 2 hours before bedtime.
Warnings: Do not exceed the recommended daily dose. Not intended for use by pregnant or lactating women, children under 12, or by individuals who are being treated with antidepressants or with kidney failure. Food supplements are not a substitute for a balanced and varied diet and healthy lifestyle.
Net Weight: 72 g.
Presentation: 120 capsules.
The results obtained after taking a food supplement depend on the correct use of the product, the time of consumption and the specific response of each organism. Food supplements have the function of supplementing the diet and supporting specific physiological functions, they are not intended to treat diseases. This function corresponds to medicines. All Nutribiolite products are not intended to replace medications and neither does it dispense with medical advice in situations of illness.
+ Quality
Nutribiolite develops top-quality natural supplements, based on the most recent scientific literature, and make them available to everyone at a fair and reasonable price.
SUITABLE FOR VEGANS AND VEGETARIANS. 100% NATURAL, WITHOUT SYNTHETIC ADDITIVES. GLUTEN FREE, LACTOSE FREE, SUGAR FREE. GMO FREE: Free of genetically modified ingredients (GMO) in accordance with Regulation (EU) 1169/2011. BSE/TSE FREE: In accordance with Regulation (CE) 999/2001 and Directives 99/742/CE and 97/534/CE. NON-IRRADIATED: In accordance with Directives 1999/2/CE and 1000/3/CE. FREE OF CONTAMINANTS: In accordance with Regulations (EU) 1881/2006 and 629/2008. LABELING: The labeling of our products conforms to Regulation (EU) No. 1169/2011 and its subsequent amendments, with the aim of guaranteeing a high level of consumer protection in relation to the food information. PACKAGING: Our packaging complies with Regulation (CE) No. 1935/2004 and its subsequent amendments, on materials and objects intended to come into contact with food, with the aim of ensure a high level of protection of human health and the interest of consumers. RAW MATERIALS: All our raw materials are of the highest quality and have a traceability system from their origin. All our ingredients are analyzed by standardized physical, chemical and microbiological tests, amply meeting the safety and quality specifications required by national and European authorities. MADE IN SPAIN under strict standards of good manufacturing practices, traceability and the strictest quality protocols, from origin to final product.
Extracted from the EFSA health claims application list, under evaluation: ID 2446 – Griffonia (Griffonia simplicifolia) – Nervous system function – For improvement of brain activity. Available from: https://open.efsa.europa.eu/questions/EFSA-Q-2008-3179.
Extracted from the EFSA health claims application list, under evaluation: ID 2348 – Valerian extract [Dry extract from roots of Valeriana officinalis L., drug/native extract ratio(3 – 6) : 1, solvent of extraction Ethanol/Water, min 0.3% valerenic acid] – For isomnia and mental health – To help sleep onset. help normalise/promote sleep (onset). Valerian helps to maintain a natural sleep.; Available from: https://open.efsa.europa.eu/questions/EFSA-Q-2008-3081.
Extracted from the EFSA health claims application list, under evaluation: ID 2349 – Valerian extract [Dry extract from roots of Valeriana officinalis L., drug/native extract ratio(3 – 6) : 1, solvent of extraction Ethanol/Water, min 0.3% valerenic acid] – For mental health – To support calmness and in case of irritability. Helps you to cope calmly with the stress of a busy lifestyle. Support of mental well-being in cases of tension and stress. Contributes to optimal relaxation. Helps to support the relaxation.; Available from: https://open.efsa.europa.eu/questions/EFSA-Q-2008-3082.
Extracted from the EFSA health claims application list, under evaluation: ID 2088 – Chamomile (Matricaria recutita/Matricaria chamomilla) – Relaxation – Contributes to optimal relaxation/helps to support the relaxation and mental and physical wel-being/contributes to a normal helps to maintain a healthy sleep.; Available from: https://open.efsa.europa.eu/questions/EFSA-Q-2008-2821.
Trauner, G., et al., Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. Planta Med, 2008. 74(1): p. 19-24.
Khom, S., et al., Valerenic acid potentiates and inhibits GABAA receptors: Molecular mechanism and subunit specificity. Neuropharmacology, 2007. 53(1): p. 178-187.
Hanrahan, J.R., M. Chebib, and G.A.R. Johnston, Flavonoid modulation of GABA(A) receptors. British journal of pharmacology, 2011. 163(2): p. 234-245.
4 powerful ingredients to help improve your sleep A key to a healthy life is getting a good night’s sleep. It is during sleep when our body performs its main restorative functions, such as tissue regeneration, muscle growth and protein synthesis. During this time, it is possible to replenish energy and regulate metabolism, essential factors […]
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