🌙_Melatonin is a hormone produced mainly by the pineal gland (located in the back of the brain), derived from another hormone, serotonin. Melatonin is extremely important in regulating the body’s biological clock (circadian cycle or sleep-wake cycle) and energy metabolism. Each capsule of 4Sleep contains 1mg of melatonin.
Melatonin helps alleviate the subjective sensation of jet lag. The beneficial effect is obtained with a minimum intake of 0.5 mg, which should be taken shortly before bedtime on the first day of travel and a few days after arrival at the destination1.
Melatonin helps reduce the time needed to fall asleep. The beneficial effect is obtained with an intake of 1 mg of melatonin shortly before going to sleep1.
🌙_5-HTP, also known as oxitriptan, is the precursor amino acid in the biosynthesis of the neurotransmitter serotonin, which plays a key role in regulating almost all functions of the central nervous system, such as mood, anxiety, stress, appetite, cognition, and sexual behavior. Each capsule of 4Sleep contains 49 mg of 5HTP. The EFSA (European Food Safety Agency) is evaluating the health claim “improvement of brain activity” regarding this plant (EFSA-Q-2008-3179).
🌙_Valerian root extract is rich in valerenic acid. This substance has been shown to have the ability to modulate GABA-A receptors, producing a suppressive effect on neuronal activity, increasing relaxation, reducing stress and shortening the time it takes to fall asleep2-4. The EFSA is evaluating several health claims regarding this plant, for example: it helps to initiate sleep and maintain its quality (EFSA-Q-2008-3413, EFSA-Q-2008-4771) and supports mental well-being (EFSA -Q-2008-4932).
🌙_Chamomile flower extract is well known for its relaxing properties. These are due to the presence of apigenin, a flavonoid polyphenol that is very abundant in the flowers of this plant and that constitutes 68% of its total flavonoid content5. According to several studies, apigenin can act as a second-order modulator of GABA-A receptors, that is, a modulator that enhances the effect of endogenous agents that modulate GABA-A receptors6. EFSA is evaluating various health claims related to chamomile as its contribution to relaxation (EFSA-Q-2010-00538) and the maintenance of healthy sleep (EFSA-Q-2010-00586).